"And Here's the Kicker" by Mike Sacks is a collection of interviews of top comics, from standup to sitcom writing. There was definitely a lot of misery in there. There's the Simpsons writer who graduated from Harvard and still pined over girls who ignored him in high school. Or the creator of the Onion who flat out said, "I'm miserable!" and talked about how humor is connected to pain. In fact Sacks noted to one comedian how unusual it seemed that he didn't have any baggage, and that guy mentioned getting lunch with other comedians is terrible because it's like they all have Asperger syndrome.