Another classic HLL vs. C argument: the anecdotal slow C program. Clearly, of these, there are many great examples. Unfortunately, it's a crappy argument, because there are also a zillion incredibly slow HLL programs.
I don't think stcredzero meant that as an argument that C is worse than HLL -- it was just a warning that, as with any tool, it can be improperly used.
I'm certainly not against C. I've just used C to write an embedded controller for doing real-time mixing of PWM control signals and laser gyroscope data for a model tilt-wing aircraft. (Which should be able to convert between horizontal and vertical modes in-flight.) I wouldn't use Smalltalk for that. (Yet. If I had 10X more CPU to burn, maybe.) Likewise, I'm not going to write my next Commodities Trading app in C.
That is a false dilemma tho'. No-one in the Python world has anything invested in a 100% Python solution to anything. Doing the compute-intensive bits in C is in fact expected and encouraged! The same is true in the Tcl camp. Maybe some HLL communities (Java?) like to be "pure" but I've not ever encountered that.
Java communities typically favor portability (and easy deployment) over what you can gain in terms of speed. A lot of libraries/frameworks actually even advertise themselves as "100% pure java", whereas one might expect "expensive bits optimized in C" as attractive as well (but you rarely see it).