Feel free to add citations, but the most recent findings seem to suggest no negative impacts.
Psychedelics bring forth what needs to be looked at; if one doesn’t have an intention or support to do that, they may want to want until they do.
The same could probably be said for falling in love or starting a company as well.
In fact, my guess is that romantic relationships and entrepreneurship probably trigger “underlying mental issues” with at least as much frequency as psychedelics.