Sorry if I was being ambiguous. All mice are less resistant to cancer than humans, even wild type mice. Mice in nature rarely live long enough to get cancer, but if you put them up in a mouse retirement home (lab), a large percentage of wild mice will get spontaneous cancers.
Yes mouse cancer in not a great model for human cancer and we probably should not be using mice - about the only good thing they have going for them as a model is they are small and cheap.
Personally I would like to see us using pets (dogs and cats) much more as their cancers are a much better match to human cancers in both how they develop and how they progress. That we are not taking better advantage of this resource to develop new treatments is a tragedy.
I suspect one reason could be that mice have much faster metabolisms than humans. Also, typically the speed of metabolism is typically inversely correlated with size, although there definitely are some outliers too.
Mice have far few cells than humans so they should be much less likely to get cancer (all things being equal). Peto’s paradox is all about this effect [1].
Yes mouse cancer in not a great model for human cancer and we probably should not be using mice - about the only good thing they have going for them as a model is they are small and cheap.
Personally I would like to see us using pets (dogs and cats) much more as their cancers are a much better match to human cancers in both how they develop and how they progress. That we are not taking better advantage of this resource to develop new treatments is a tragedy.